Clinical Evaluation of the YASH-T Decoction in the management of mild to moderate COVID-19 patients: open label-controlled trial


2020 onwards

NPR 50 Lakh

Ministry of Health and Population (MoHP)

Selected Hospitals of different provinces (Bagmati Province and Province 2)

The world is in the midst of COVID 19 pandemic and accounts for more than 3 million deaths globally. Currently, there are no approved drugs available and hence several studies are going on in search of suitable drugs that can target viral proteins or host receptors for the management of COVID-19.  There are several vaccines available for COVID 19 and at least 7 vaccines have been administered. Since the vaccines are newly developed, information about the strength of protection and effectiveness are yet to be studied. In this scenario, the search for plant-based antiviral agents against the SARS-CoV-2 could be promising because several plants have been shown to possess antiviral activities against different viruses.

COVID 19 shows flu or influenza like symptoms which mostly resemble the common cold. Ayurvedic medicines have been used since the Vedic period and they have a long history for treatment of viral diseases.

COVID-19 disease seems symptoms like the common cold; and has been considered under respiratory disease. It progresses to bilateral pneumonia at a later stage and causes death due to respiratory failure. Ayurvedic medicines have been used in Indian subcontinent since the Vedic period and they have a long history for treatment of viral diseases . Ayurveda has multifold treatment options for respiratory disorders such as running nose, headache, dry cough, sore throat, difficulty in breath, body ache . Yashtimadhu and Trikatu have been mentioned several times in Ayurveda classics for treatment of common cold, bronchitis, cough and hiccups. Hence this study may provide an alternate therapy to COVID 19 from a herbal origin.

  • To assess effectiveness of YASH-T decoction in the management of COVID-19 cases in Nepal
  • To assess clinical features in symptomatic COVID-19 cases after the intervention of the test drug.
  • To compare the hematological parameters in the COVID-19 cases before and after the intervention.

  • Effectiveness of Ayurvedic Polyherbal formulation in the treatment of COVID 19 will be assessed
  • If proven effective it can be used as add on treatment in COVID 19