Exploring the anti-diabetic properties from the traditionally used Nepalese medicinal plants and Ayurvedic formulation
Technical working group comprising of members from MOHP, DDA, GODAN, ADAN, IOM Ayurveda Campus, and consultants in related fields were organized. After conducting a series of meetings, MoU was established between NHRC and CDC (Central Department of Chemistry) in conducting the study in an organized and systematic way. Plants have been collected for conducting the further study.
NPR 5 Million
Ministry of Health and Population (MoHP)
Kathmandu, Lalitpur and Bhaktapur
Knowledge of herbal medicinal practitioners in accordance to the one described in Ayurveda, some medicinal plants have been reported to have shown anti-diabetic properties. This year it has been planned to complete the preliminary steps, by collecting the medicinal plants which are identified to have anti-diabetic properties along with the extraction of such contents from those plants. In accordance with the above-mentioned strategy, a continuation would be given to the exploration of traditionally used Nepalese medicinal plants and Ayurvedic formulations. The plan for next year would be to enroll a new drug candidate for diabetes.
To generate the evidence-based drug discovery from the traditionally used medicinal plants and Ayurvedic formulations for diabetes.
- To evaluate the in vitro enzyme (alpha-glycosidase, alpha-amylase.) inhibition assay inhibition by plant extracts
- To perform a kinetic study of the inhibitors and to evaluate type and mechanisms of inhibition
- To evaluate the toxicity of these extract on the suitable model such as brine-shrimp lethality assay
Potent anti-diabetic pure and fully characterized compounds could be isolated from plants if their crude extracts or semi-pure fraction will exhibit a good result.